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Neuroepigenetic Architectures in the Mouse and Human Brain

Amanda C. Mitchell, Ph.D.


  • Date and time: January 19, 2017 from 3:30pm-4:30 pm
  • Location: 310 Kelly Hall
  • Speaker: Amanda C. Mitchell, Ph.D.
  • Affiliation: Postdoctoral Fellow, Icahn School of Medicine at Mt. Sinai


The neuronal epigenome is composed of DNA and histone modifications and
higher order chromatin structures. Its architecture changes during the course
development and with respect to function in the normal and diseased mouse and
human brain. We have begun to link the neuronal epigenome to functional
behaviors and provide signatures of how changes in the neuronal epigenome affect
behavior. Using publically available schizophrenia datasets we have predicted key
transcriptional targets associated with the disorder. Overexpression of these targets
in the prefrontal cortex of mice has revealed associations with working memory
and social cognition behaviors. Furthermore, we have developed a tool to mark
neuronal epigenomes over the course of development in the mouse brain to link
previous exposures to present day behavior.

For more information, contact Anne Wailes :


* Amanda Mitchell Seminar Flyer.pdf
Neuroepigenetic Architectures in the Mouse and Human Brain