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Elizabeth R. Gilbert

  • Ph.D. in Molecular Biology and Animal Nutrition, Virginia Polytechnic Institute and State University
3620 Litton-Reaves
Animal & Poultry Sciences Department
Blacksburg, VA 24061-0306

From an undergraduate degree in wildlife biology to a postdoctoral research position in the area of comparative genomics, I have always had a strong interest in the evolutionary basis of complex traits and adaptations that confer unique physiological attributes to different species. My Master’s and Ph.D. research focused on the regulation of gene expression of intestinal nutrient transporters in black bears and birds and through this research I cultivated my passion for nutritional science and molecular biology, in particular the understanding of how nutrients regulate gene expression and cellular functions. I completed a postdoctoral appointment in the area of pancreatic beta cell regeneration where I identified plant-based compounds with effects on beta cell proliferation and viability in culture and confirmed their anti-diabetic effects in a mouse model. I also conducted postdoctoral research in the area of nutritional proteomics; using a mass spectrometric-based approach to identify proteins involved in the development of the small intestine in birds from lines that had undergone selection for growth under different nutritional environments. My final postdoctoral project, in the Department of Medical Biochemistry and Medical Biology at Uppsala University in Uppsala, Sweden, involved characterizing the function of a transcription factor that was identified as a repressor of insulin-like growth factor 2, ZBED6, using a variety of functional genomics-based approaches in different cell types. I assumed a tenure-track faculty position at Virginia Tech in 2012 and have since established a research program that focuses on understanding the molecular basis for eating disorders, insulin resistance, and obesity, using chicks as the primary research model.

My research is aimed at developing strategies to reduce the prevalence of obesity and eating disorders. I use birds as a model to study interactions of genetic background, diet, hormone and neuropeptide, and developmental effects on regulation of appetite, adipose tissue physiology and insulin resistance. The overarching objective of my research is to elucidate molecular mechanisms and cellular signaling pathways associated with adipose development, with an emphasis on the brain-fat axis. Using a primary cell culture platform and in vivo approaches, we have studied how various appetite-regulating peptides, such as neuropeptide Y and alpha-melanocyte stimulating hormone, regulate appetite-associated pathways in the hypothalamus and also adipogenesis, adipocyte hypertrophy, and lipolysis in the adipose tissue. We are also researching the impact of early-life nutrition and stress exposure on metabolic outcomes later in life, with an emphasis on epigenetic changes associated with appetite-regulatory factors in the hypothalamus. The Virginia lines of chickens, existing only at Virginia Tech, serve as an important model for this research. These lines originate from a common founder population and for more than 60 consecutive generations have been selected for low and high body weight, which has led to correlated responses in appetite and body composition. The anorexic line consists of lean individuals with varying severities of anorexia, whereas the obese line consists of compulsive feeders that all become obese. From a biomedical perspective, these lines are a valuable resource for researching eating disorders and communication between the brain and adipose tissue. From an agricultural perspective, this research has direct relevance to improving animal production efficiency.

I am also passionate about teaching and instruct animal nutrition and cellular and molecular neuroscience courses at Virginia Tech.

1: Wang G, Cline MA, Gilbert ER. Responses to peripheral neuropeptide Y in avian adipose tissue are diet, depot, and time specific. Gen Comp Endocrinol. 2018 Jun 1;262:12-19. doi: 10.1016/j.ygcen.2018.03.007. Epub 2018 Mar 3. PubMed PMID: 29510148.

2: McConn BR, Gilbert ER, Cline MA. Appetite-associated responses to central neuropeptide Y injection in quail. Neuropeptides. 2018 Jun;69:9-18. doi:  10.1016/j.npep.2018.03.001. Epub 2018 Mar 9. PubMed PMID: 29573813.  

3: Zhang S, Gilbert ER, Noonan KJT, Saremi B, Wong EA. Gene expression and activity of methionine converting enzymes in broiler chickens fed methionine isomers or precursors. Poult Sci. 2018 Jun 1;97(6):2053-2063. doi: 10.3382/ps/pey037. PubMed PMID: 29514286.

4: Liu L, Xiao Q, Gilbert ER, Cui Z, Zhao X, Wang Y, Yin H, Li D, Zhang H, Zhu Q. Whole-transcriptome analysis of atrophic ovaries in broody chickens reveals regulatory pathways associated with proliferation and apoptosis. Sci Rep. 2018 May 8;8(1):7231. doi: 10.1038/s41598-018-25103-6. PubMed PMID: 29739971; PubMed Central PMCID: PMC5940789. 

5: McConn BR, Matias J, Wang G, Cline MA, Gilbert ER. Dietary macronutrient composition affects hypothalamic appetite regulation in chicks. Nutr Neurosci. 2018 Jan;21(1):49-58. doi: 10.1080/1028415X.2016.1219103. Epub 2016 Aug 16. PubMed PMID: 27686011.

6: Wang J, Yi J, Siegel PB, Cline MA, Gilbert ER. Stress-induced suppression of neuropeptide Y-induced hunger in anorexic chicks involves corticotrophin-releasing factor signalling and the paraventricular nucleus of the hypothalamus. J Neuroendocrinol. 2017 Dec;29(12). doi: 10.1111/jne.12555. PubMed  PMID: 29121414. 

7: Liu L, Wang G, Xiao Y, Shipp SL, Siegel PB, Cline MA, Gilbert ER. Peripheral neuropeptide Y differentially influences adipogenesis and lipolysis in chicks from lines selected for low or high body weight. Comp Biochem Physiol A Mol Integr Physiol. 2017 Nov;213:1-10. doi: 10.1016/j.cbpa.2017.08.001. Epub 2017 Aug 5. PubMed PMID: 28789975.

8: Lear T, Liu L, O'Donnell M, McConn BR, Denbow DM, Cline MA, Gilbert ER. Alpha-melanocyte stimulating hormone-induced anorexia in Japanese quail (Coturnix japonica) likely involves the ventromedial hypothalamus and paraventricular nucleus of the hypothalamus. Gen Comp Endocrinol. 2017 Oct 1;252:97-102. doi: 10.1016/j.ygcen.2017.08.005. Epub 2017 Aug 4. PubMed PMID: 28782535.  

9: Wang G, Kim WK, Cline MA, Gilbert ER. Factors affecting adipose tissue development in chickens: A review. Poult Sci. 2017 Oct 1;96(10):3687-3699. doi: 10.3382/ps/pex184. Review. PubMed PMID: 28938790. 

10: Wang G, Williams CA, McConn BR, Cline MA, Gilbert ER. A high fat diet enhances the sensitivity of chick adipose tissue to the effects of centrally injected neuropeptide Y on gene expression of adipogenesis-associated factors. Comp Biochem Physiol A Mol Integr Physiol. 2017 Sep;211:49-55. doi: 10.1016/j.cbpa.2017.06.006. Epub 2017 Jun 16. PubMed PMID: 28625910.

11: Sims W, Yi J, Cline MA, Gilbert ER. Central injection of a synthetic chicken  partial leptin peptide does not affect food intake in chicks. Neurosci Lett. 2017 Aug 24;656:165-168. doi: 10.1016/j.neulet.2017.07.038. Epub 2017 Jul 24. PubMed PMID: 28751205. 

12: Yuan J, Gilbert ER, Cline MA. The central anorexigenic mechanism of amylin in Japanese quail (Coturnix japonica) involves pro-opiomelanocortin, calcitonin receptor, and the arcuate nucleus of the hypothalamus. Comp Biochem Physiol A Mol Integr Physiol. 2017 Aug;210:28-34. doi: 10.1016/j.cbpa.2017.05.011. Epub 2017 May 26. PubMed PMID: 28552562.

13: Yi J, Yuan J, Gilbert ER, Siegel PB, Cline MA. Differential expression of appetite-regulating genes in avian models of anorexia and obesity. J Neuroendocrinol. 2017 Aug;29(8). doi: 10.1111/jne.12510. PubMed PMID: 28727208. 

14: Shipp SL, Wang G, Cline MA, Gilbert ER. Chick subcutaneous and abdominal adipose tissue depots respond differently in lipolytic and adipogenic activity to α-melanocyte stimulating hormone (α-MSH). Comp Biochem Physiol A Mol Integr Physiol. 2017 Jul;209:56-64. doi: 10.1016/j.cbpa.2017.04.013. Epub 2017 Apr 22. PubMed PMID: 28438719.

15: Delp MS, Cline MA, Gilbert ER. The central effects of alpha-melanocyte stimulating hormone (α-MSH) in chicks involve changes in gene expression of neuropeptide Y and other factors in distinct hypothalamic nuclei. Neurosci Lett.  2017 Jun 9;651:52-56. doi: 10.1016/j.neulet.2017.04.064. Epub 2017 May 1. PubMed  PMID: 28473259. 

16: Scheel A, Deal N, St John N, Wells A, Caruso M, Gilbert ER, Cline M. LPLRFamide exerts short-term anorexigenic effects that coincide with magnocellular division of the hypothalamic paraventricular nucleus activation. Gen Comp Endocrinol. 2017 May 15;246:116-119. doi: 10.1016/j.ygcen.2016.06.023. Epub 2016 Jun 16. PubMed PMID: 27318277.

17: Matias JA, Gilbert ER, Denbow DM, Cline MA. Effects of intracerebroventricular injection of rosiglitazone on appetite-associated parameters in chicks. Gen Comp Endocrinol. 2017 May 15;246:99-104. doi: 10.1016/j.ygcen.2015.12.021. Epub 2015 Dec 23. PubMed PMID: 26723189. 

18: Zhang W, Didehvar D, Wang G, Yi J, Gilbert ER, Cline MA. Anorexigenic effect  of serotonin is associated with changes in hypothalamic nuclei activity in an avian model. Gen Comp Endocrinol. 2017 May 15;246:81-87. doi: 10.1016/j.ygcen.2015.03.014. Epub 2015 May 8. PubMed PMID: 25963044.

19: Wang G, McConn BR, Liu D, Cline MA, Gilbert ER. The effects of dietary macronutrient composition on lipid metabolism-associated factor gene expression in the adipose tissue of chickens are influenced by fasting and refeeding. BMC Obes. 2017 May 10;4:14. doi: 10.1186/s40608-017-0150-8. eCollection 2017. PubMed  PMID: 28496985; PubMed Central PMCID: PMC5424285. 

20: McConn BR, Cline MA, Gilbert ER. Dietary macronutrient composition and central neuropeptide Y injection affect dietary preference and hypothalamic gene  expression in chicks. Nutr Neurosci. 2017 Mar 10:1-11. doi: 10.1080/1028415X.2017.1296606. [Epub ahead of print] PubMed PMID: 28279130.

21: Zhang H, Gilbert ER, Zhang K, Ding X, Luo Y, Wang J, Zeng Q, Bai S. Uptake of manganese from manganese-lysine complex in the primary rat intestinal epithelial  cells. J Anim Physiol Anim Nutr (Berl). 2017 Feb;101(1):147-158. doi: 10.1111/jpn.12430. Epub 2015 Dec 15. PubMed PMID: 26671483. 

22: Zhang S, Saremi B, Gilbert ER, Wong EA. Physiological and biochemical aspects of methionine isomers and a methionine analogue in broilers. Poult Sci. 2017 Feb  1;96(2):425-439. doi: 10.3382/ps/pew253. Epub 2016 Aug 30. PubMed PMID: 27578876.

23: Shipp SL, Cline MA, Gilbert ER. Promotion of adipogenesis by neuropeptide Y during the later stages of chicken preadipocyte differentiation. Physiol Rep. 2016 Nov;4(21). pii: e13006. PubMed PMID: 27803314; PubMed Central PMCID: PMC5112489.  

24: Shipp SL, Cline MA, Gilbert ER. Recent advances in the understanding of how neuropeptide Y and α-melanocyte stimulating hormone function in adipose physiology. Adipocyte. 2016 Jul 13;5(4):333-350. eCollection 2016 Oct-Dec. Review. PubMed PMID: 27994947; PubMed Central PMCID: PMC5160404. 

25: McConn BR, Yi J, Gilbert ER, Siegel PB, Chowdhury VS, Furuse M, Cline MA. Stimulation of food intake after central administration of gonadotropin-inhibitory hormone is similar in genetically selected low and high body weight lines of chickens. Gen Comp Endocrinol. 2016 Jun 1;232:96-100. doi: 10.1016/j.ygcen.2016.01.004. Epub 2016 Jan 4. PubMed PMID: 26764213.

26: Yi J, Delp MS, Gilbert ER, Siegel PB, Cline MA. Anorexia is Associated with Stress-Dependent Orexigenic Responses to Exogenous Neuropeptide Y. J Neuroendocrinol. 2016 May;28(5). doi: 10.1111/jne.12378. PubMed PMID: 26924179. 

27: Zhang H, Gilbert ER, Pan S, Zhang K, Ding X, Wang J, Zeng Q, Bai S. Dietary iron concentration influences serum concentrations of manganese in rats consuming organic or inorganic sources of manganese. Br J Nutr. 2016 Feb 28;115(4):585-93.  doi: 10.1017/S0007114515004900. PubMed PMID: 26824729.

28: Davis M, Jessee R, Close M, Fu X, Settlage R, Wang G, Cline MA, Gilbert ER. Fasting for 21days leads to changes in adipose tissue and liver physiology in juvenile checkered garter snakes (Thamnophis marcianus). Comp Biochem Physiol A Mol Integr Physiol. 2015 Dec;190:68-74. doi: 10.1016/j.cbpa.2015.09.001. Epub 2015 Sep 7. PubMed PMID: 26358832. 

29: Shipp SL, Smith ML, Gilbert ER, Cline MA. Beta-cell-tropin is associated with short-term stimulation of food intake in chicks. Gen Comp Endocrinol. 2015 Dec 1;224:278-82. doi: 10.1016/j.ygcen.2015.08.004. Epub 2015 Aug 4. PubMed PMID: 26248228.

30: Wang G, Tachibana T, Gilbert ER, Cline MA. Exogenous prolactin-releasing peptide's orexigenic effect is associated with hypothalamic neuropeptide Y in chicks. Neuropeptides. 2015 Dec;54:79-83. doi: 10.1016/j.npep.2015.08.004. Epub 2015 Aug 14. PubMed PMID: 26349952. 

31: Liu L, Li D, Gilbert ER, Xiao Q, Zhao X, Wang Y, Yin H, Zhu Q. Effect of Monochromatic Light on Expression of Estrogen Receptor (ER) and Progesterone Receptor (PR) in Ovarian Follicles of Chicken. PLoS One. 2015 Dec 1;10(12):e0144102. doi: 10.1371/journal.pone.0144102. eCollection 2015. PubMed PMID: 26624893; PubMed Central PMCID: PMC4666490.

32: Bai S, Wang G, Zhang W, Zhang S, Rice BB, Cline MA, Gilbert ER. Broiler chicken adipose tissue dynamics during the first two weeks post-hatch. Comp Biochem Physiol A Mol Integr Physiol. 2015 Nov;189:115-23. doi: 10.1016/j.cbpa.2015.08.002. Epub 2015 Aug 8. PubMed PMID: 26263851. 

33: Parker GA, Sumners LH, Zhao X, Honaker CF, Siegel PB, Cline MA, Gilbert ER. Delayed access of low body weight-selected chicks to food at hatch is associated  with up-regulated pancreatic glucagon and glucose transporter gene expression. Comp Biochem Physiol A Mol Integr Physiol. 2015 Nov;189:124-9. doi: 10.1016/j.cbpa.2015.08.004. Epub 2015 Aug 8. PubMed PMID: 26260898.

34: McConn BR, Park J, Gilbert ER, Cline MA. A novel role for xenopsin: Stimulation of food intake. Behav Brain Res. 2015 Oct 1;292:500-7. doi: 10.1016/j.bbr.2015.06.039. Epub 2015 Jul 4. PubMed PMID: 26151286.

35: Wang G, Tachibana T, Gilbert ER, Cline MA. Dietary Macronutrient Composition  Affects the Influence of Exogenous Prolactin-Releasing Peptide on Appetite Responses and Hypothalamic Gene Expression in Chickens. J Nutr. 2015 Oct;145(10):2406-11. doi: 10.3945/jn.115.214338. Epub 2015 Sep 9. PubMed PMID: 26355003. 

36: Shipp SL, Yi J, Dridi S, Gilbert ER, Cline MA. The central anorexigenic mechanism of adrenocorticotropic hormone involves the caudal hypothalamus in chicks. Neuropeptides. 2015 Oct;53:29-35. doi: 10.1016/j.npep.2015.07.005. Epub 2015 Aug 8. PubMed PMID: 26297349.

37: Zhang L, Zhu Q, Liu Y, Gilbert ER, Li D, Yin H, Wang Y, Yang Z, Wang Z, Yuan  Y, Zhao X. Polymorphisms in the Perilipin Gene May Affect Carcass Traits of Chinese Meat-type Chickens. Asian-Australas J Anim Sci. 2015 Jun;28(6):763-70. doi: 10.5713/ajas.14.0554. PubMed PMID: 25925053; PubMed Central PMCID: PMC4412972. 

38: Yi J, Gilbert ER, Siegel PB, Cline MA. Fed and fasted chicks from lines divergently selected for low or high body weight have differential hypothalamic appetite-associated factor mRNA expression profiles. Behav Brain Res. 2015 Jun 1;286:58-63. doi: 10.1016/j.bbr.2015.02.008. Epub 2015 Feb 10. PubMed PMID: 25677648.

39: Zhang S, Wong EA, Gilbert ER. Bioavailability of different dietary supplemental methionine sources in animals. Front Biosci (Elite Ed). 2015 Jun 1;7:478-90. Review. PubMed PMID: 25961426. 

40: Zhang W, Kim S, Settlage R, McMahon W, Sumners LH, Siegel PB, Dorshorst BJ, Cline MA, Gilbert ER. Hypothalamic differences in expression of genes involved in monoamine synthesis and signaling pathways after insulin injection in chickens from lines selected for high and low body weight. Neurogenetics. 2015 Apr;16(2):133-44. doi: 10.1007/s10048-014-0435-8. Epub 2015 Jan 13. PubMed PMID:  25582322.

41: Nelson LA, Gilbert ER, Cline MA. Effects of dietary macronutrient composition on exogenous neuropeptide Y's stimulation of food intake in chicks. Neurosci Lett. 2015 Mar 30;591:171-5. doi: 10.1016/j.neulet.2015.02.017. Epub 2015 Feb 11. Erratum in: Neurosci Lett. 2015 May 19;595():114-5. PubMed PMID: 25681626.   

42: Zhang W, Bai S, Liu D, Cline MA, Gilbert ER. Neuropeptide Y promotes adipogenesis in chicken adipose cells in vitro. Comp Biochem Physiol A Mol Integr Physiol. 2015 Mar;181:62-70. doi: 10.1016/j.cbpa.2014.11.012. Epub 2014 Nov 22. PubMed PMID: 25461485.

43: Li Q, Zhao XL, Gilbert ER, Liu YP, Wang Y, Qiu MH, Zhu Q. Confined housing system increased abdominal and subcutaneous fat deposition and gene expressions of carbohydrate response element-binding protein and sterol regulatory element-binding protein 1 in chicken. Genet Mol Res. 2015 Feb 6;14(1):1220-8. doi: 10.4238/2015.February.6.24. PubMed PMID: 25730060. 

44: McConn B, Wang G, Yi J, Gilbert ER, Osugi T, Ubuka T, Tsutsui K, Chowdhury VS, Furuse M, Cline MA. Gonadotropin-inhibitory hormone-stimulation of food intake is mediated by hypothalamic effects in chicks. Neuropeptides. 2014 Dec;48(6):327-34. doi: 10.1016/j.npep.2014.09.001. Epub 2014 Sep 11. PubMed PMID: 25305807.

45: Rice BB, Zhang W, Bai S, Siegel PB, Cline MA, Gilbert ER. Insulin-induced hypoglycemia associations with gene expression changes in liver and hypothalamus  of chickens from lines selected for low or high body weight. Gen Comp Endocrinol. 2014 Nov 1;208:1-4. doi: 10.1016/j.ygcen.2014.08.010. Epub 2014 Aug 23. PubMed PMID: 25157791. 

46: Zhang S, McMillan RP, Hulver MW, Siegel PB, Sumners LH, Zhang W, Cline MA, Gilbert ER. Chickens from lines selected for high and low body weight show differences in fatty acid oxidation efficiency and metabolic flexibility in skeletal muscle and white adipose tissue. Int J Obes (Lond). 2014 Oct;38(10):1374-82. doi: 10.1038/ijo.2014.8. Epub 2014 Jan 20. PubMed PMID: 24441038.

47: Mace JD, Tachibana T, Wang G, Newmyer BA, Guilliams E, Gilbert ER, Cline MA.  Substance P is associated with hypothalamic paraventricular nucleus activation that coincides with increased urotensin 2 mRNA in chicks. Neuropeptides. 2014 Oct;48(5):305-11. doi: 10.1016/j.npep.2014.06.001. Epub 2014 Jun 24. PubMed PMID: 25005752. 

48: Wang Y, Xu HY, Gilbert ER, Peng X, Zhao XL, Liu YP, Zhu Q. Detection of SNPs  in the TBC1D1 gene and their association with carcass traits in chicken. Gene. 2014 Sep 1;547(2):288-94. doi: 10.1016/j.gene.2014.06.061. Epub 2014 Jun 27. PubMed PMID: 24979340.

49: Wang G, Brumfield B, DiCroce M, Nelson L, Newmyer BA, Flower J, Hipskind K, Sharma S, Gilbert ER, Cline MA. Anorexigenic effects of central adrenomedullin are associated with hypothalamic changes in juvenile Gallus gallus. Gen Comp Endocrinol. 2014 Aug 1;204:223-8. doi: 10.1016/j.ygcen.2014.05.032. Epub 2014 Jun 11. PubMed PMID: 24929231. 

50: Zhang W, Cline MA, Gilbert ER. Hypothalamus-adipose tissue crosstalk: neuropeptide Y and the regulation of energy metabolism. Nutr Metab (Lond). 2014 Jun 10;11:27. doi: 10.1186/1743-7075-11-27. eCollection 2014. Review. PubMed PMID: 24959194; PubMed Central PMCID: PMC4066284.  

51: Sumners LH, Zhang W, Zhao X, Honaker CF, Zhang S, Cline MA, Siegel PB, Gilbert ER. Chickens from lines artificially selected for juvenile low and high body weight differ in glucose homeostasis and pancreas physiology. Comp Biochem Physiol A Mol Integr Physiol. 2014 Jun;172:57-65. doi: 10.1016/j.cbpa.2014.02.020. Epub 2014 Mar 5. PubMed PMID: 24614025.

52: Li J, Zhao XL, Gilbert ER, Li DY, Liu YP, Wang Y, Zhu Q, Wang YG, Chen Y, Tian K. APOBEC2 mRNA and protein is predominantly expressed in skeletal and cardiac muscles of chickens. Gene. 2014 Apr 15;539(2):263-9. doi: 10.1016/j.gene.2014.01.003. Epub 2014 Jan 15. PubMed PMID: 24440786. 

53: Jiang L, Wallerman O, Younis S, Rubin CJ, Gilbert ER, Sundström E, Ghazal A,  Zhang X, Wang L, Mikkelsen TS, Andersson G, Andersson L. ZBED6 modulates the transcription of myogenic genes in mouse myoblast cells. PLoS One. 2014 Apr 8;9(4):e94187. doi: 10.1371/journal.pone.0094187. eCollection 2014. PubMed PMID:  24714595; PubMed Central PMCID: PMC3979763.

54: Yin HD, Tian K, Li DY, Gilbert ER, Xiao LH, Chen SY, Wang Y, Liu YP, Zhao XL, Zhu Q. Expression Profiles of Cellular Retinol-binding Protein, Type II (CRBP II) in Erlang Mountainous Chickens. Asian-Australas J Anim Sci. 2014 Mar;27(3):310-5. doi: 10.5713/ajas.2013.13469. PubMed PMID: 25049956; PubMed Central PMCID: PMC4093264. 

55: Zhao X, Sumners LH, Gilbert ER, Siegel PB, Zhang W, Cline M. Delayed feeding  after hatch caused compensatory increases in blood glucose concentration in fed chicks from low but not high body weight lines. Poult Sci. 2014 Mar;93(3):617-24. doi: 10.3382/ps.2013-03551. PubMed PMID: 24604855.

56: Zhang S, Hulver MW, McMillan RP, Cline MA, Gilbert ER. The pivotal role of pyruvate dehydrogenase kinases in metabolic flexibility. Nutr Metab (Lond). 2014  Feb 12;11(1):10. doi: 10.1186/1743-7075-11-10. PubMed PMID: 24520982; PubMed Central PMCID: PMC3925357. 

57: Zou P, Liu L, Zheng L, Liu L, Stoneman RE, Cho A, Emery A, Gilbert ER, Cheng  Z. Targeting FoxO1 with AS1842856 suppresses adipogenesis. Cell Cycle. 2014;13(23):3759-67. doi: 10.4161/15384101.2014.965977. PubMed PMID: 25483084; PubMed Central PMCID: PMC4613185.

58: Yin H, Zhang S, Gilbert ER, Siegel PB, Zhu Q, Wong EA. Expression profiles of muscle genes in postnatal skeletal muscle in lines of chickens divergently selected for high and low body weight. Poult Sci. 2014 Jan;93(1):147-54. doi: 10.3382/ps.2013-03612. PubMed PMID: 24570434. 

59: Zhang W, Sumners LH, Siegel PB, Cline MA, Gilbert ER. Quantity of glucose transporter and appetite-associated factor mRNA in various tissues after insulin  injection in chickens selected for low or high body weight. Physiol Genomics. 2013 Nov 15;45(22):1084-94. doi: 10.1152/physiolgenomics.00102.2013. Epub 2013 Sep 17. PubMed PMID: 24046279.

60: Babu PV, Liu D, Gilbert ER. Recent advances in understanding the anti-diabetic actions of dietary flavonoids. J Nutr Biochem. 2013 Nov;24(11):1777-89. doi: 10.1016/j.jnutbio.2013.06.003. Epub 2013 Sep 9. Review.  PubMed PMID: 24029069; PubMed Central PMCID: PMC3821977. 

61: Zhang W, Cline MA, Liu D, Gilbert ER. Knockdown of ZBED6 is not associated with changes in murine preadipocyte proliferation or differentiation. Adipocyte.  2013 Oct 1;2(4):251-5. doi: 10.4161/adip.26028. Epub 2013 Aug 13. PubMed PMID: 24052901; PubMed Central PMCID: PMC3774701.

62: Yin HD, Gilbert ER, Chen SY, Wang Y, Zhang ZC, Zhao XL, Zhang Y, Zhu Q. Effect of hybridization on carcass traits and meat quality of erlang mountainous  chickens. Asian-Australas J Anim Sci. 2013 Oct;26(10):1504-10. doi: 10.5713/ajas.2013.13097. PubMed PMID: 25049734; PubMed Central PMCID: PMC4093072. 

63: Yin HD, Gilbert ER, Chen SY, Li DY, Zhang ZC, Wang Y, Liu YP, Zhu Q. Ontogenic expression pattern and genetic polymorphisms of the retinol-binding protein 4 (RBP4) gene in Erlang mountainous chickens. Gene. 2013 Sep 10;526(2):170-5. doi: 10.1016/j.gene.2013.05.017. Epub 2013 May 23. PubMed PMID:  23707795.

64: Hagen CJ, Newmyer BA, Webster RI, Gilbert ER, Siegel PB, Tachibana T, Cline MA. Stimulation of food intake after central galanin is associated with arcuate nucleus activation and does not differ between genetically selected low and high  body weight lines of chickens. Neuropeptides. 2013 Aug;47(4):281-5. doi: 10.1016/j.npep.2012.11.003. Epub 2013 Jan 29. PubMed PMID: 23369300. 

65: Webster RI, Newmyer BA, Furuse M, Gilbert ER, Cline MA. The orexigenic effect of kyotorphin in chicks involves hypothalamus and brainstem activity and opioid receptors. Neuropeptides. 2013 Jun;47(3):193-8. doi: 10.1016/j.npep.2012.10.007.  Epub 2012 Dec 20. PubMed PMID: 23261360.

66: Li J, Zhao XL, Yuan YC, Gilbert ER, Wang Y, Liu YP, Zhang Y, Zhu Q. Dietary lysine affects chickens from local Chinese pure lines and their reciprocal crosses. Poult Sci. 2013 Jun;92(6):1683-9. doi: 10.3382/ps.2012-02865. PubMed PMID: 23687167. 

67: Li J, Chen Y, Wang YG, Zhao XL, Gilbert ER, Liu YP, Wang Y, Hu YD, Zhu Q. MUSTN1 mRNA Abundance and Protein Localization is Greatest in Muscle Tissues of Chinese Meat-Quality Chickens. Int J Mol Sci. 2013 Mar 8;14(3):5545-59. doi: 10.3390/ijms14035545. PubMed PMID: 23528857; PubMed Central PMCID: PMC3634495.

68: Gilbert ER, Liu D. Anti-diabetic functions of soy isoflavone genistein: mechanisms underlying its effects on pancreatic β-cell function. Food Funct. 2013 Feb;4(2):200-12. doi: 10.1039/c2fo30199g. Review. PubMed PMID: 23160185; PubMed Central PMCID: PMC3678366. 

69: Fu Z, Gilbert ER, Liu D. Regulation of insulin synthesis and secretion and pancreatic Beta-cell dysfunction in diabetes. Curr Diabetes Rev. 2013 Jan 1;9(1):25-53. Review. PubMed PMID: 22974359; PubMed Central PMCID: PMC3934755.

70: Lamichhaney S, Martinez Barrio A, Rafati N, Sundström G, Rubin CJ, Gilbert ER, Berglund J, Wetterbom A, Laikre L, Webster MT, Grabherr M, Ryman N, Andersson L. Population-scale sequencing reveals genetic differentiation due to local adaptation in Atlantic herring. Proc Natl Acad Sci U S A. 2012 Nov 20;109(47):19345-50. doi: 10.1073/pnas.1216128109. Epub 2012 Nov 7. PubMed PMID:  23134729; PubMed Central PMCID: PMC3511109. 

71: Zhao XL, Siegel PB, Liu YP, Wang Y, Gilbert ER, Zhu Q, Zhang L. Housing system affects broiler characteristics of local Chinese breed reciprocal crosses. Poult Sci. 2012 Sep;91(9):2405-10. doi: 10.3382/ps.2012-02165. PubMed PMID: 22912481.

72: Gilbert ER, Liu D. Epigenetics: the missing link to understanding β-cell dysfunction in the pathogenesis of type 2 diabetes. Epigenetics. 2012 Aug;7(8):841-52. doi: 10.4161/epi.21238. Epub 2012 Jul 19. Review. PubMed PMID: 22810088; PubMed Central PMCID: PMC3427279. 

73: Fu Z, Gilbert ER, Pfeiffer L, Zhang Y, Fu Y, Liu D. Genistein ameliorates hyperglycemia in a mouse model of nongenetic type 2 diabetes. Appl Physiol Nutr Metab. 2012 Jun;37(3):480-8. doi: 10.1139/h2012-005. Epub 2012 Apr 17. PubMed PMID: 22509809; PubMed Central PMCID: PMC4337421.

74: Dilling DF, Gilbert ER, Picken MM, Eby JM, Love RB, Le Poole IC. A current viewpoint of lymphangioleiomyomatosis supporting immunotherapeutic treatment options. Am J Respir Cell Mol Biol. 2012 Jan;46(1):1-5. doi: 10.1165/rcmb.2011-0215TR. Review. PubMed PMID: 21940815. 

75: Casterlow S, Li H, Gilbert ER, Dalloul RA, McElroy AP, Emmerson DA, Wong EA.  An antimicrobial peptide is downregulated in the small intestine of Eimeria maxima-infected chickens. Poult Sci. 2011 Jun;90(6):1212-9. doi: 10.3382/ps.2010-01110. PubMed PMID: 21597061.

76: Wu G, Siegel PB, Gilbert ER, Yang N, Wong EA. Expression profiles of somatotropic axis genes in lines of chickens divergently selected for 56-day body weight. Anim Biotechnol. 2011 Apr;22(2):100-10. doi: 10.1080/10495398.2011.566450. PubMed PMID: 21500111. 

77: Gilbert ER. Editorial preface to the second issue of 2011. J Cardiovasc Dis Res. 2011 Apr;2(2):89-90. doi: 10.4103/0975-3583.83032. PubMed PMID: 21814411; PubMed Central PMCID: PMC3144624.

78: Gilbert ER, Cox CM, Williams PM, McElroy AP, Dalloul RA, Ray WK, Barri A, Emmerson DA, Wong EA, Webb KE Jr. Eimeria species and genetic background influence the serum protein profile of broilers with coccidiosis. PLoS One. 2011  Jan 31;6(1):e14636. doi: 10.1371/journal.pone.0014636. Erratum in: PLoS One. 2011;6(2). doi: 10.1371/annotation/e9373e8a-b316-49c6-b33f-f49557453b48. PubMed PMID: 21297942; PubMed Central PMCID: PMC3031500. 

79: Gilbert ER, Fu Z, Liu D. Development of a nongenetic mouse model of type 2 diabetes. Exp Diabetes Res. 2011;2011:416254. doi: 10.1155/2011/416254. Epub 2011 Nov 29. PubMed PMID: 22164157; PubMed Central PMCID: PMC3226533.

80: Gilbert ER, Williams PM, Ray WK, Li H, Emmerson DA, Wong EA, Webb KE Jr. Proteomic evaluation of chicken brush-border membrane during the early posthatch  period. J Proteome Res. 2010 Sep 3;9(9):4628-39. doi: 10.1021/pr1003533. PubMed PMID: 20687565.

81: Gilbert ER, Li H, Emmerson DA, Webb KE Jr, Wong EA. Dietary protein composition influences abundance of peptide and amino acid transporter messenger  ribonucleic acid in the small intestine of 2 lines of broiler chicks. Poult Sci.  2010 Aug;89(8):1663-76. doi: 10.3382/ps.2010-00801. PubMed PMID: 20634522.

82: Gilbert ER, Liu D. Flavonoids influence epigenetic-modifying enzyme activity: structure - function relationships and the therapeutic potential for cancer. Curr Med Chem. 2010;17(17):1756-68. Review. PubMed PMID: 20345345.

83: Gilbert ER, Wong EA, Webb KE Jr. Board-invited review: Peptide absorption and utilization: Implications for animal nutrition and health. J Anim Sci. 2008 Sep;86(9):2135-55. doi: 10.2527/jas.2007-0826. Epub 2008 Apr 25. Review. PubMed PMID: 18441086.

84: Li H, Gilbert ER, Zhang Y, Crasta O, Emmerson D, Webb KE Jr, Wong EA. Expression profiling of the solute carrier gene family in chicken intestine from  the late embryonic to early post-hatch stages. Anim Genet. 2008 Aug;39(4):407-24. doi: 10.1111/j.1365-2052.2008.01744.x. Epub 2008 Jun 9. PubMed PMID: 18544075.

85: Gilbert ER, Li H, Emmerson DA, Webb KE Jr, Wong EA. Dietary protein quality and feed restriction influence abundance of nutrient transporter mRNA in the small intestine of broiler chicks. J Nutr. 2008 Feb;138(2):262-71. PubMed PMID: 18203889.

86: Gilbert ER, Li H, Emmerson DA, Webb KE Jr, Wong EA. Developmental regulation  of nutrient transporter and enzyme mRNA abundance in the small intestine of broilers. Poult Sci. 2007 Aug;86(8):1739-53. PubMed PMID: 17626820.  87: Gilbert ER, Wong EA, Vaughan M, Webb KE Jr. Distribution and abundance of nutrient transporter mRNA in the intestinal tract of the black bear, Ursus americanus. Comp Biochem Physiol B Biochem Mol Biol. 2007 Jan;146(1):35-41. Epub  2006 Sep 6. PubMed PMID: 17035058.